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Genetics

Principles of inheritance, monohybrid and dihybrid crosses, sex-linked traits, and genetic disorders.

📘 Topic Summary

Genetics is the study of how traits are passed down from parents to offspring through genes. This topic covers the principles of inheritance, monohybrid and dihybrid crosses, sex-linked traits, and genetic disorders.

📖 Glossary
  • Gene: A unit of heredity that carries information from one generation to the next.
  • Chromosome: A thread-like structure made up of DNA and proteins that carries genes in a cell.
  • Dominant: A gene or trait that is expressed when an individual has two copies of it, either two dominant alleles or one dominant allele and one recessive allele.
  • Recessive: A gene or trait that is only expressed when an individual has two copies of it, two recessive alleles.
⭐ Key Points
  • Genes are made up of DNA and contain the instructions for making proteins.
  • Chromosomes come in pairs, one inherited from each parent.
  • Dominant genes will always be expressed if an individual has one copy of it.
  • Recessive genes will only be expressed if an individual has two copies of it.
  • Genetic disorders can occur when there is a mutation or change in the DNA sequence.
🔍 Subtopics
Principles of Inheritance

Inheritance is the passing of traits from parents to offspring through the transmission of genetic information encoded in DNA. The principles of inheritance were first described by Gregor Mendel, who discovered that traits are inherited in a predictable manner according to specific rules. These rules include the law of segregation, which states that each pair of alleles separates during gamete formation, and the law of independent assortment, which states that different genes are sorted independently into gametes. The combination of these laws allows for the prediction of the probability of certain traits being expressed in offspring.

Monohybrid Crosses

A monohybrid cross is a mating between two individuals that differ by one pair of alleles, where each individual is homozygous or heterozygous for the same gene. The possible outcomes of a monohybrid cross are determined by the Punnett square, which shows the probability of each possible genotype and phenotype. For example, if a tall plant (TT) is crossed with a short plant (tt), the offspring can be either tall (Tt) or short (tt). The ratio of tall to short offspring is 3:1 in favor of the dominant trait.

Dihybrid Crosses

A dihybrid cross is a mating between two individuals that differ by two pairs of alleles, where each individual is homozygous or heterozygous for both genes. The possible outcomes of a dihybrid cross are also determined by the Punnett square. For example, if a plant with red flowers (RR) and yellow seeds (yy) is crossed with a plant with white flowers (rr) and green seeds (YY), the offspring can have different combinations of flower color and seed color. The ratio of offspring with red flowers and yellow seeds to those with white flowers and green seeds is 9:3:3:1.

Sex-Linked Traits

Sex-linked traits are inherited in a way that is dependent on the sex of the individual. In humans, females have two X chromosomes (XX), while males have one X and one Y chromosome (XY). Sex-linked traits are determined by genes located on the X or Y chromosomes. For example, the gene for red-green color vision is located on the X chromosome, which means that women can be carriers of the trait but men cannot inherit it directly.

Genetic Disorders

Genetic disorders are conditions caused by mutations in one or more genes. They can be inherited in an autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive pattern. Examples of genetic disorders include sickle cell anemia, cystic fibrosis, and Huntington's disease. These disorders can have significant effects on the individual and their family members.

🧠 Practice Questions

  1. What is the primary function of genes?

  2. What is the term for a trait that is only expressed when an individual has two copies of it, two recessive alleles?

  3. What is the name of the scientist who discovered the principles of inheritance?

  4. What is a dihybrid cross?

  5. What is a sex-linked trait?

  6. What is a genetic disorder?

  7. What is the term for a gene or trait that is expressed when an individual has one copy of it, either two dominant alleles or one dominant allele and one recessive allele?

  8. What is the name of the type of cross that involves two individuals with different genotypes for a single gene?

  9. What is the term for a trait that is determined by genes located on the X chromosome?

  10. What is the term for a condition caused by mutations in one or more genes that can be inherited in an autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive pattern?

  1. What is the probability of a tall plant being produced when a tall plant (TT) is crossed with a short plant (tt)? (2 marks)

  2. What is the ratio of offspring with red flowers and yellow seeds to those with white flowers and green seeds when a plant with red flowers (RR) and yellow seeds (yy) is crossed with a plant with white flowers (rr) and green seeds (YY)? (2 marks)

  3. What is the probability of an individual expressing a recessive trait if they have one copy of the gene? (2 marks)

  4. What is the term for a condition caused by mutations in one or more genes that can affect the development and function of an organism? (2 marks)

  5. What is the name of the scientist who discovered the structure of DNA? (2 marks)

  1. Discuss the importance of genetics in understanding human traits and characteristics. (20 marks)

  2. Explain how genetic disorders can affect individuals and families. (20 marks)